microBrain® 3D Assay Ready – LOPAC

High Throughput Screening of LOPAC Using the microBrain® 3D Assay Ready Platform

There is an increasing emphasis on using biologically relevant human neural cell-based assays in drug discovery to better mimic the complexity of the human brain and improve predictivity of in vitro drug screening assays. To this end, human induced Pluripotent Stem Cell (iPSC)-derived neural cells offer great potential for modeling neurological diseases and have found application in drug discovery for high content and phenotypic-based drug screening. However, lack of consistency limits their application for high throughput screening (HTS) and subsequent preclinical assay applications where low variability and high reproducibility are critical requirements for drug discovery and development.

  • microBrain 3D Assay Ready is a highly consistent and scalable platform for high throughput screening studies
  • 111 LOPAC compounds demonstrated neuromodulatory activity in microBrain spheroids at a single screening dose of 1μM
  • microBrain 3D Assay Ready 384-Well Plates demonstrate high intra- and inter-plate consistency

Ordering Information

Product Name Catalog #
microBrain 3D Assay Ready 96-Well Plate Call for Information
microBrain 3D Assay Ready 384-Well Plate BSARX-AA-0384

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