World Preclinical Congress Podium Talk
IPS CELLS FOR CNS DRUG DISCOVERY AND DEVELOPMENT
Tuesday, June 19, 2:20 PM
Fabian Zanella, PhD, Director, Research & Development
We present human induced pluripotent stem cell (hiPSC)-based platforms which were structurally engineered with greater physiological relevance aimed to elevate performance in drug discovery applications. microBrain® 3D comprises cortical neural spheroids that feature high functionality with robust spontaneous activity and expected responses to established neuromodulators. microHeart® allows cardiomyocytes to adopt cell geometries and intercellular organization that resemble native heart tissue, translating into to differential pharmacological response to known cardioactive compounds.