Forming 3D Neuronal Models of the Brain
November 2019 – An interview with Dr Grischa Chandy, conducted at SfN 2018 by Alina Shrourou, BSc.
How can 3D imaging and analysis improve our understanding of the brain?
The ability to acquire and analyze 3D dimensions provides a more physiologically relevant model to study. With 3D imaging and analysis, researchers can study physiology and pathophysiology in the 3D context. For example, instead of a sample with just neurons, it can be a 3D sample with neurons and astrocytes, enabling researchers to gain a greater understanding of neurodegenerative disease and discover potential therapeutics.
What is a 3D neuronal model and how can these be used to develop potential therapeutics?
With induced pluripotent stem cell (iPSC) technologies, it is possible to generate 3D models from individual patients and correlate the patient’s genome with phenotype and functional response to potential drug candidates. StemoniX®, one of the companies we collaborate with, has developed a 3D neural assay model for high-content, high-throughput screening.
StemoniX® is transforming how medicine is discovered. By using skin or blood to create functioning microHearts® and microBrains®, StemoniX is making it possible to test medication on humans without that medication ever entering their bodies. This method of drug testing will speed up the search for new cures and enable the ability to test drug effectiveness on an individual person, so medicine works correctly the first time. For more information visit www.stemonix.com.
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